What to Expect When Coming off Abilify – Common Symptoms and Withdrawal Effects

Symptoms of Coming Off Abilify

When abruptly stopping the medication Abilify (aripiprazole), individuals may experience a range of withdrawal symptoms. It is important to note that the severity and duration of these symptoms can vary from person to person. Here are some common symptoms that may occur when coming off Abilify:

1. Nausea and vomiting

One of the most frequently reported symptoms during withdrawal from Abilify is nausea. Some individuals may also experience vomiting. These gastrointestinal symptoms can be uncomfortable and may last for several days or weeks as the body adjusts to the absence of the medication.

2. Dizziness and lightheadedness

Dizziness and lightheadedness are other common withdrawal symptoms. Individuals may feel unsteady on their feet or have trouble with balance. These symptoms may persist for a few days or weeks before gradually subsiding.

3. Insomnia or sleep disturbances

When discontinuing Abilify, some individuals may experience difficulty falling asleep or disrupted sleep patterns. This can lead to fatigue, irritability, and difficulties in concentration during the day. These symptoms usually resolve within a few weeks as the body readjusts.

4. Anxiety and agitation

Abruptly stopping Abilify can also trigger feelings of anxiety and agitation. Some individuals may experience restlessness, irritability, or increased nervousness. These symptoms may be temporary and fade away over time as the body adapts to the absence of the medication.

5. Muscle stiffness or tremors

Muscle stiffness and tremors are potential withdrawal symptoms when coming off Abilify. Some individuals may experience involuntary muscle movements or repetitive motions. These symptoms typically improve within a few weeks, but if they persist or worsen, it is important to seek medical advice.

6. Headache

Headaches are another reported symptom during Abilify withdrawal. These headaches can range from mild to severe and may last for a few days or weeks. Staying hydrated, practicing relaxation techniques, and over-the-counter pain relievers can help manage this symptom.

7. Flu-like symptoms

A small number of individuals may experience flu-like symptoms when discontinuing Abilify. These symptoms can include fever, body aches, chills, and fatigue. It is important to rest, stay hydrated, and seek medical attention if these symptoms become severe or persistent.

8. Rebound symptoms

In some cases, individuals may experience a reemergence of the symptoms that Abilify was originally prescribed to treat. This phenomenon is known as rebound symptoms and can include the return of depression, anxiety, or psychosis. It is essential to work closely with a healthcare professional when discontinuing Abilify to manage any potential rebound symptoms effectively.

9. Slow tapering for minimizing withdrawal

To minimize the risk and severity of withdrawal symptoms, it is recommended to gradually taper off Abilify under the guidance of a healthcare professional. Slow tapering helps the body adjust to the absence of the medication in a more controlled manner, reducing the likelihood of experiencing severe withdrawal symptoms.


As with any medication, abruptly discontinuing Abilify can result in various withdrawal symptoms. It is crucial to work closely with a healthcare professional when deciding to come off Abilify to ensure a safe and comfortable transition. Each individual may experience different symptoms and durations, so a personalized approach is essential. If you or someone you know is considering stopping Abilify, it is important to seek medical advice to create an appropriate plan for withdrawal.

The Symptoms of Coming off Abilify

When abruptly stopping the medication Abilify (aripiprazole), it is common for individuals to experience withdrawal symptoms. These symptoms can range from mild discomfort to more severe effects, depending on the person and their dosage. Understanding the potential symptoms can help individuals anticipate and manage the process of coming off Abilify.

1. Flu-like Symptoms

One common symptom experienced when discontinuing Abilify is flu-like symptoms. These may include a runny nose, cough, headache, muscle aches, and fatigue. These symptoms are similar to those experienced during a typical flu, but without the presence of an infection.

2. Insomnia

Insomnia, or difficulty sleeping, is another common symptom of coming off Abilify. This can manifest as trouble falling asleep, staying asleep, or waking up earlier than desired. Sleep disturbances can disrupt daily functioning and lead to increased irritability and fatigue.

3. Nausea and Upset Stomach

Many individuals experience gastrointestinal symptoms when discontinuing Abilify, such as nausea, vomiting, and stomach pain. These symptoms can make it difficult to eat and may result in weight loss or poor appetite.

4. Mood Swings

Abilify withdrawal can also bring about mood swings, ranging from irritability and agitation to feelings of depression or anxiety. These emotional changes can be challenging to manage and may require additional support or therapy.

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5. Dizziness and Headaches

Dizziness and headaches are common withdrawal symptoms experienced when stopping Abilify. This can make it difficult to focus or concentrate and may require adjustments to daily activities.

6. Sensory Disturbances

Some individuals may experience sensory disturbances when discontinuing Abilify. This can include heightened sensitivity to light, sound, or touch, as well as experiencing unusual sensations such as tingling or numbness.

It is important to note that not everyone will experience these symptoms, and their severity can vary from person to person. If you are considering coming off Abilify, it is essential to discuss this decision with your healthcare provider to ensure a safe and appropriate plan is in place.

Withdrawal from psychiatric medications can be challenging, and individuals should seek support from their healthcare team to manage the process effectively. With proper guidance and support, individuals can successfully navigate the withdrawal process and minimize the impact of these symptoms.

Symptoms of coming off Abilify

When abruptly stopping the medication Abilify (aripiprazole), individuals may experience a range of symptoms known as withdrawal or discontinuation symptoms. These symptoms can vary in severity and duration depending on factors such as the dosage of the medication, the length of time it was taken, and individual differences in metabolism.

1. Physical symptoms

  • Headaches: Some individuals may experience headaches upon discontinuing Abilify. These headaches can vary in intensity and may be accompanied by other physical symptoms.
  • Nausea and vomiting: Discontinuation of Abilify may also lead to feelings of nausea and vomiting. This can be distressing for individuals and may require additional medical support.
  • Insomnia: Difficulty sleeping or insomnia is another common symptom of coming off Abilify. This can disrupt a person’s daily routine and affect their overall well-being.
  • Dizziness: Dizziness may occur as the body adjusts to the absence of Abilify. It can cause lightheadedness or a feeling of being off balance.
  • Flu-like symptoms: Some individuals may experience flu-like symptoms such as body aches, fatigue, and chills when discontinuing Abilify.
  • Agitation: Feelings of restlessness, irritability, or agitation can also occur during withdrawal from Abilify. These symptoms can interfere with daily activities and should be monitored closely.

2. Emotional and psychological symptoms

  • Anxiety: Coming off Abilify can trigger or worsen symptoms of anxiety. This may include feelings of worry, panic, or unease.
  • Depression: Discontinuation of Abilify can sometimes lead to a temporary worsening of depression symptoms. It is important to seek professional support if these symptoms become severe or persist.
  • Mood swings: Individuals may experience sudden changes in mood, including irritability, sadness, or anger when discontinuing Abilify. These mood swings can be disruptive to daily life.
  • Difficulty concentrating: Some people may experience trouble focusing or concentrating when coming off Abilify. This can impact work, school, and other daily activities.

3. Rebound symptoms

When discontinuing Abilify, some individuals may experience a return or worsening of the symptoms the medication was originally prescribed for. This is known as rebound symptoms and can include:

  • Psychosis: People who were prescribed Abilify to manage symptoms of psychosis may experience a recurrence of psychotic episodes upon discontinuation of the medication.
  • Mood disorders: For individuals with mood disorders such as bipolar disorder, stopping Abilify can result in a relapse or intensification of symptoms. This may include manic or depressive episodes.
  • Anxiety disorders: Individuals who were using Abilify to manage anxiety disorders may experience a resurgence of anxiety symptoms when they stop taking the medication.

It is important to note that these rebound symptoms can be severe and may require immediate medical attention. It is always recommended to work closely with a healthcare professional when discontinuing any medication, including Abilify.
Study on antipsychotic discontinuation symptoms
American Psychiatric Association: Withdrawal from Medications

Symptoms of coming off Abilify

1. Gradual vs Abrupt discontinuation

The symptoms of coming off Abilify (aripiprazole) can vary depending on whether the discontinuation is done gradually or abruptly. Gradual discontinuation involves slowly reducing the dosage over a period of time, while abrupt discontinuation involves stopping the medication suddenly.

Gradual discontinuation

Gradual discontinuation of Abilify allows the body to adjust to the lower dosage, minimizing the risk of withdrawal symptoms. This method is generally recommended for individuals who have been taking the medication for an extended period of time or at higher doses.

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Abrupt discontinuation

Abrupt discontinuation of Abilify can lead to a more severe and noticeable onset of symptoms. The sudden withdrawal can disrupt the chemical balance in the brain, resulting in a variety of physical and psychological effects.

2. Psychological symptoms

When coming off Abilify, individuals may experience various psychological symptoms. These can include:

  • Agitation
  • Anxiety
  • Depression
  • Irritability
  • Mood swings
  • Insomnia

It is important to note that these symptoms can vary in severity and duration, with some individuals experiencing more intense symptoms than others. Consulting a healthcare professional is recommended to properly manage and address these psychological symptoms.

3. Physical symptoms

In addition to psychological symptoms, individuals may also experience physical symptoms when coming off Abilify. These can include:

  • Nausea
  • Vomiting
  • Dizziness
  • Headaches
  • Fatigue
  • Flu-like symptoms

These physical symptoms can be disruptive and uncomfortable, making it important to seek medical guidance during the discontinuation process.

4. Risk of relapse

One of the main concerns when coming off Abilify is the risk of relapse. Abilify is commonly prescribed for the treatment of various mental health conditions, such as schizophrenia, bipolar disorder, and major depressive disorder. Discontinuing the medication can potentially lead to a recurrence of symptoms or a relapse of the underlying condition.
Studies have shown that individuals who abruptly stop taking antipsychotic medications, like Abilify, have a higher risk of relapse compared to those who gradually taper off the medication. It is important to consult with a healthcare professional to develop a safe and effective plan for discontinuation to minimize the risk of relapse.

5. Individual experiences

It is important to recognize that each individual may have unique experiences when coming off Abilify. Factors such as the duration of medication use, dosage, and individual physiology can determine the severity and duration of withdrawal symptoms.
While some individuals may experience minimal symptoms and successfully transition off the medication, others may require additional support and monitoring during the discontinuation process.


Coming off Abilify can be a complex process and should be done under the guidance of a healthcare professional. Gradual discontinuation is generally recommended to minimize withdrawal symptoms and reduce the risk of relapse. It is important to be aware of the potential psychological and physical symptoms that may arise and seek appropriate support during this transition.

5. Precautions and Safety Measures to Consider when Coming off Abilify

When discontinuing any medication, including Abilify, it is important to take certain precautions and consider safety measures. Here are some recommendations to keep in mind:

1. Consult with a Healthcare Professional

Always consult with your healthcare professional before stopping Abilify. They can provide guidance based on your specific situation and help you develop a withdrawal plan. Abruptly stopping the medication can lead to withdrawal symptoms or a relapse of your condition, so it’s essential to have medical supervision.

2. Gradually Taper Off the Medication

To minimize the risk of withdrawal symptoms, it is generally recommended to taper off Abilify gradually. Your healthcare professional will determine the appropriate tapering schedule based on factors such as your dosage, duration of treatment, and your individual response to the medication.

3. Monitor for Withdrawal Symptoms

During the tapering process, it’s important to monitor for any withdrawal symptoms. These may include insomnia, anxiety, irritability, dizziness, nausea, sweating, or flu-like symptoms. If you experience any of these symptoms, it’s crucial to inform your healthcare professional for further guidance.

4. Consider Adjunctive Therapies

In some cases, healthcare professionals may recommend adjunctive therapies to help manage withdrawal symptoms and support the transition off Abilify. These may include psychotherapy, support groups, or other non-pharmacological interventions.

5. Communicate Openly with Your Doctor

Throughout the process of coming off Abilify, maintaining open communication with your healthcare professional is crucial. They can provide you with the necessary support, monitor your progress, and make adjustments to your tapering plan as needed. Be sure to discuss any concerns or changes in symptoms with them.

6. Monitor Your Mental Well-being

As you come off Abilify, it is important to pay attention to your mental well-being. If you notice any significant changes in your mood or symptoms worsening, contact your healthcare professional immediately. They can evaluate your condition and make any necessary adjustments to ensure your safety and well-being.
It is worth noting that everyone’s experience when coming off Abilify may vary, and it is important to follow the guidance of your healthcare professional. The above precautions and safety measures can help ensure a smoother transition and minimize the risks associated with discontinuing the medication abruptly.
– National Institute of Mental Health. (2018). Bipolar Disorder. Retrieved from https://www.nimh.nih.gov/health/topics/bipolar-disorder/index.shtml
– FDA. (2020). ABILIFY Oral Solution. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/021436s055lbl.pdf

6. Tips for Managing Withdrawal Symptoms

6.1. Gradual tapering

One of the most important steps in managing withdrawal symptoms from Abilify is to gradually taper off the medication. Abruptly stopping the medication can lead to more severe withdrawal symptoms. It is recommended to work closely with a healthcare professional to create a tapering schedule that gradually reduces the dosage over time.

6.2. Support from a healthcare professional

Seeking support from a healthcare professional during the withdrawal process can be crucial. They can provide guidance and monitor the individual’s progress, ensuring that any withdrawal symptoms are properly managed. Additionally, a healthcare professional can offer alternative treatment options or adjustments to medication if necessary.

6.3. Communication with loved ones

It is important for individuals going through withdrawal from Abilify to communicate with their loved ones about their experiences. This can help others understand the challenges and provide emotional support during this time. Having a support system in place can make a significant difference in managing withdrawal symptoms.

6.4. Self-care practices

Engaging in self-care activities can help alleviate some of the discomfort associated with withdrawal symptoms. Partaking in activities such as exercise, mindfulness techniques, and relaxation exercises can help reduce anxiety, improve mood, and promote overall well-being. It is important to find activities that work best for the individual.

6.5. Healthy lifestyle choices

Opting for a healthy lifestyle can also contribute to managing withdrawal symptoms. This includes maintaining a balanced diet, getting regular exercise, and prioritizing sleep. These lifestyle choices can support the body’s natural healing process and improve overall well-being.

6.6. Seeking professional counseling

For some individuals, professional counseling may be beneficial in managing withdrawal symptoms. A therapist or counselor can provide additional support and guidance during this challenging time. They can help individuals develop coping mechanisms, address any underlying emotional issues, and provide a safe space for expressing concerns and emotions.

6.7. Educating oneself

Knowledge is power when it comes to managing withdrawal symptoms. Taking the time to educate oneself about the potential symptoms and challenges can help individuals anticipate and better cope with them. Reliable sources such as medical literature, reputable websites, and support groups can provide valuable information and insights.

6.8. Patience and self-compassion

Withdrawal from Abilify can be a difficult and challenging process. It is important for individuals to practice patience and self-compassion during this time. Recognizing that withdrawal symptoms are a normal part of the process and giving oneself permission to rest and heal can aid in managing the journey more effectively.

7. Risk of relapse

When coming off Abilify, there is a risk of relapse. According to a study published in the Journal of Clinical Psychopharmacology, approximately 30-40% of individuals who discontinued Abilify experienced a relapse within 6-12 months.

This risk of relapse can be attributed to the fact that Abilify is often prescribed to individuals with schizophrenia, bipolar disorder, or major depressive disorder, which are chronic conditions. Discontinuing the medication can disrupt the delicate balance of neurotransmitters in the brain, leading to a recurrence of symptoms.

Relapse can occur in various forms, depending on the individual’s underlying condition. For those with schizophrenia, a relapse may involve a return of hallucinations, delusions, or disorganized thinking. Individuals with bipolar disorder may experience manic or depressive episodes again, while those with major depressive disorder may relapse into a state of persistent sadness and loss of interest.

To minimize the risk of relapse, it is important for individuals to work closely with their healthcare providers when discontinuing Abilify. Gradual tapering of the medication, under medical supervision, can help reduce the likelihood of relapse and allow for the adjustment of any necessary alternative treatments.

It is also crucial for individuals to be aware of the early signs of relapse, which can vary depending on the individual’s condition. These signs may include changes in mood, sleep patterns, appetite, or overall functioning. Recognizing these signs and seeking prompt medical attention can help prevent a full-blown relapse.

Furthermore, maintaining a comprehensive treatment plan that includes therapy, lifestyle modifications, and other appropriate interventions can also help support individuals coming off Abilify and reduce the risk of relapse.

Category: Abilify

Tags: Abilify, Aripiprazole